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The Human Skin Microbiome in Selected Cutaneous Diseases
Silvia Carmona-Cruz1, Luz Orozco-Covarrubias1, Marimar Sáez-de-Ocariz1
1Department of Dermatology, Instituto Nacional de Pediatría, Mexico City, Mexico.
Frontiers in Cellular and Infection Microbiology
|March 24, 2022
Summary
The human skin microbiome, comprising microbes and their genes, is increasingly linked to skin disease development. Understanding these microbial communities and their immune interactions offers new therapeutic avenues for conditions like eczema and acne.
Area of Science:
- Microbiology
- Immunology
- Dermatology
Background:
- The human skin hosts a diverse microbial community, forming the skin microbiome.
- Alterations in the skin microbiome are implicated in the development of various skin diseases.
- Interactions between the skin microbiome and host immune systems are crucial for skin health.
Purpose of the Study:
- To review recent findings on the skin microbiome.
- To explore the role of the skin microbiome in the pathogenesis of specific skin disorders.
Main Methods:
- Literature review of recent studies on the skin microbiome.
- Analysis of the involvement of cutaneous microbiota in dermatoses.
Main Results:
- The skin microbiome plays a significant role in skin health and disease.
- Specific skin conditions like atopic dermatitis, seborrheic dermatitis, alopecia areata, psoriasis, and acne are associated with alterations in the skin microbiome.
Conclusions:
- A deeper understanding of the skin microbiome and its immune interactions can improve disease understanding.
- Targeting the skin microbiome presents potential new therapeutic strategies for dermatological conditions.
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