Related Experiment Video
Updated: Sep 29, 2025
04:33
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
839
Depressive Symptoms and Incident Hospitalization for Heart Failure: Findings From the REGARDS Study
Yulia Khodneva1, Parag Goyal2,3, Emily B Levitan4
1Department of Medicine School of Medicine University of Alabama at Birmingham AL.
Journal of the American Heart Association
|March 24, 2022
Summary
Depressive symptoms are linked to heart failure hospitalizations, particularly HFpEF, in adults without prior coronary heart disease. This association was not found for HFrEF or in those with existing CHD.
Area of Science:
- Cardiology
- Psychiatry
- Epidemiology
Background:
- Depressive symptoms are established risk factors for coronary heart disease (CHD).
- The association between depressive symptoms and incident heart failure (HF), including its subtypes, remains unclear.
- Understanding this link is crucial for comprehensive cardiovascular disease prevention and management.
Purpose of the Study:
- To investigate the association between depressive symptoms and incident heart failure (HF) hospitalizations.
- To examine if this association differs for HF with preserved ejection fraction (HFpEF) versus HF with reduced ejection fraction (HFrEF).
- To determine if baseline coronary heart disease (CHD) modifies the relationship between depressive symptoms and incident HF.
Main Methods:
- Analysis of 26,268 HF-free participants from the REGARDS study (US adults ≥45 years).
- Baseline depressive symptoms assessed using the Center for Epidemiologic Studies Depression scale (score ≥4).
- Incident HF hospitalizations adjudicated and classified as HFpEF (EF ≥50%) or HFrEF (EF <50%).
Main Results:
- Higher incidence rates of HF hospitalization observed in participants with depressive symptoms (4.9/1000 person-years) versus those without (3.2/1000 person-years).
- Depressive symptoms were associated with increased risk of HFpEF hospitalization (HR 1.48) in individuals without baseline CHD after covariate adjustment.
- No significant association found between depressive symptoms and incident HFrEF hospitalizations or any HF hospitalization in those with baseline CHD.
Conclusions:
- Depressive symptoms are associated with incident HFpEF hospitalizations among individuals without prior CHD.
- The association between depressive symptoms and heart failure hospitalization is subtype-specific (HFpEF) and dependent on baseline CHD status.
- These findings highlight the importance of addressing depressive symptoms in cardiovascular risk assessment, particularly for HFpEF prevention in at-risk populations.
Related Concept Videos
01:30Heart Failure IV: Classification and Diagnostic Evaluation
58
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
58
01:21Rheumatic Heart Disease III: Medical Management
46
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
46
01:17Pathophysiology of Heart Failure
1.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K
01:26Heart Failure III: Clinical Manifestations
68
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
68
01:27Heart Failure I: Introduction
95
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
95
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
96
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
96