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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
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Targeting triglycerides to lower residual cardiovascular risk
Kristen J Bubb1,2, Adam J Nelson2, Stephen J Nicholls2
1Biomedicine Discovery Institute, Clayto, VIC, Australia.
Expert Review of Cardiovascular Therapy
|March 24, 2022
Summary
Emerging research shows triglyceride-rich lipoproteins contribute to atherosclerosis. Targeting these lipoproteins, alongside LDL-C, may offer more effective cardiovascular disease prevention than current dyslipidemia treatments.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Current dyslipidemia therapies primarily target low-density lipoprotein cholesterol (LDL-C).
- Despite effective LDL-C lowering, many patients still experience cardiovascular events, indicating residual risk.
- Emerging evidence implicates triglyceride-rich lipoproteins (TRLs) in the causal pathway of atherosclerosis.
Purpose of the Study:
- To review evidence supporting the causal role of TRLs in atherosclerotic cardiovascular disease.
- To evaluate the utility of existing lipid-modifying therapies in targeting TRLs.
- To explore novel therapeutic agents for TRLs and their potential impact on cardiovascular risk.
Main Methods:
- Review of preclinical, observational, and genetic studies on TRLs and atherosclerosis.
- Analysis of current lipid-modifying therapies for their effects on TRLs.
- Discussion of emerging therapeutic agents targeting TRLs.
Main Results:
- Preclinical, observational, and genetic data confirm TRLs' role in atherosclerosis.
- Existing therapies can reduce residual cardiovascular risk associated with hypertriglyceridemia.
- Novel agents show potential for substantial and preferential triglyceride lowering beyond current treatments.
Conclusions:
- Triglyceride-rich lipoproteins are a key factor in atherosclerotic cardiovascular disease development.
- Targeting TRLs offers a promising strategy to mitigate residual cardiovascular risk.
- Future clinical outcomes trials will determine the precise impact of novel TRL-lowering agents on cardiovascular risk.
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