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Updated: Sep 29, 2025
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Coronary Artery Disease and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study
Tao Yan1, Shijie Zhu1, Changming Xie2
1Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Journal of Cardiovascular Development and Disease
|March 24, 2022
Summary
Coronary artery disease (CAD) increases the risk of atrial fibrillation (AF), but AF does not appear to cause CAD. Early heart rhythm monitoring is recommended for CAD patients.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Epidemiology
Background:
- Observational studies suggest coronary artery disease (CAD) and atrial fibrillation (AF) exacerbate each other.
- The causal relationship between CAD and AF remains unclear.
Purpose of the Study:
- To investigate the causal associations between CAD and AF using two-sample Mendelian randomization (TSMR).
Main Methods:
- Utilized summary-level GWAS data for CAD (CARDIoGRAMplusC4D) and AF (largest meta-analysis).
- Employed three TSMR methods: inverse-variance weighted (IVW), MR-Egger, and weighted-median.
- Harmonized genetic data for robust analysis.
Main Results:
- CAD was significantly associated with an increased risk of AF (IVW OR 1.11, MR-Egger OR 1.14, weighted-median OR 1.13).
- No significant causal association was found between AF and the risk of CAD (all p-values > 0.05).
Conclusions:
- CAD is a risk factor for developing AF.
- AF does not appear to causally increase the risk of CAD.
- Clinical recommendations include early heart rhythm monitoring in CAD patients and managing AF complications to potentially reduce CAD incidence.
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