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Ginkgo biloba in the Aging Process: A Narrative Review
Sandra Maria Barbalho1,2,3, Rosa Direito4, Lucas Fornari Laurindo2
1Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil.
Antioxidants (Basel, Switzerland)
|March 25, 2022
Summary
Ginkgo biloba (GB) may benefit aging by improving cognition and cardiovascular health. This review suggests GB aids in preventing and treating age-related conditions like neurodegenerative diseases and cancer.
Area of Science:
- Gerontology and Pharmacology
- Neuroscience
- Cardiovascular Medicine
Background:
- Aging is associated with increased risks of neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, and cancer.
- Ginkgo biloba (GB) is a herbal supplement with potential benefits for memory, cognition, and various age-related conditions.
- GB exhibits antiapoptotic, antioxidant, and anti-inflammatory properties, suggesting a role in mitigating aging processes.
Purpose of the Study:
- To conduct a narrative review on the effects of Ginkgo biloba (GB) in age-related conditions.
- To evaluate GB's impact on neurodegenerative diseases, cardiovascular disease (CVD), and cancer.
- To synthesize findings from clinical trials regarding GB's therapeutic potential in aging.
Main Methods:
- A narrative review was performed using PubMed, Cochrane, and Embase databases.
- PRISMA guidelines were followed for study selection.
- Fourteen clinical trials investigating the effects of GB were selected and analyzed.
Main Results:
- Ginkgo biloba (GB) improved memory, cognition, psychopathology, and quality of life in patients.
- GB enhanced cerebral blood flow, executive function, attention, non-verbal memory, and mood.
- GB reduced stress, fasting serum glucose, HbA1c, insulin levels, BMI, waist circumference, oxidative stress markers, and atherosclerotic plaque progression.
Conclusions:
- Ginkgo biloba (GB) demonstrates potential benefits for cognitive function and various aging-related health issues.
- GB may play a role in managing conditions such as neurodegenerative diseases, CVD, and metabolic dysfunction.
- The findings support the use of GB in the prevention and treatment strategies for age-related diseases.
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