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Updated: Sep 29, 2025
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An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
Published on: February 3, 2023
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Noncoding RNAs of Extracellular Vesicles in Tumor Angiogenesis: From Biological Functions to Clinical Significance
Miao Hu1, Juan Li2, Chen-Guang Liu1
1School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China.
Cells
|March 25, 2022
Summary
Extracellular vesicles (EVs) deliver noncoding RNAs (ncRNAs) that influence tumor angiogenesis. This review explores EV-derived ncRNAs
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Extracellular vesicles (EVs) mediate intercellular communication and influence tumor progression.
- Tumor angiogenesis, essential for tumor growth, is regulated by various cellular factors.
- EVs transfer diverse molecules, including noncoding RNAs (ncRNAs), between cells.
Purpose of the Study:
- To review the biological functions and mechanisms of EV-derived ncRNAs in tumor angiogenesis.
- To discuss the role of these ncRNAs in various cancer types.
- To explore the potential of EV-derived ncRNAs as cancer biomarkers and therapeutic targets.
Main Methods:
- Comprehensive literature review of existing research on EVs, ncRNAs, and tumor angiogenesis.
- Analysis of studies investigating the transfer and function of EV-derived ncRNAs in cancer.
- Synthesis of information regarding the clinical applications of EV-derived ncRNAs.
Main Results:
- EV-derived ncRNAs play significant roles in regulating tumor angiogenesis.
- Specific ncRNAs transferred via EVs have been identified as key mediators of angiogenesis.
- EV-derived ncRNAs contribute to malignant transformation and tumor proliferation.
Conclusions:
- EV-derived ncRNAs are critical regulators of tumor angiogenesis across various cancers.
- These ncRNAs hold promise as biomarkers for cancer diagnosis and prognosis.
- Targeting EV-derived ncRNAs offers a potential strategy for novel anti-angiogenic therapies.
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