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Updated: Sep 29, 2025

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
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Vav1 Promotes B-Cell Lymphoma Development

Batel Shalom1, Marganit Farago1, Yaser Salaymeh1

  • 1Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical School, Hebrew University, P.O. Box 12272, Jerusalem 91120, Israel.

Cells
|March 25, 2022
PubMed
Summary

Overexpression of Vav1 in non-hematopoietic tissues surprisingly induced B-cell lymphomas in mice. This suggests a novel cross-talk mechanism involving Vav1, CSF-1, and CSF-1R in tumor development.

Keywords:
B-cell lymphomaRac-GTPRosa26Vav1

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