Related Experiment Video
Updated: Sep 29, 2025
13:34
A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
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EGFR Signaling in Lung Fibrosis
Fabian Schramm1, Liliana Schaefer2, Malgorzata Wygrecka1
1Center for Infection and Genomics of the Lung (CIGL), Universities of Giessen and Marburg, 35392 Giessen, Germany.
Cells
|March 25, 2022
Summary
This review explores the ErbB receptor-ligand system
Area of Science:
- Cellular Biology
- Pulmonary Medicine
- Molecular Signaling
Background:
- The ErbB receptor-ligand system regulates critical developmental and physiological processes.
- Dysregulation of ErbB signaling is implicated in lung tissue remodeling and diseases like idiopathic pulmonary fibrosis (IPF).
Purpose of the Study:
- To review the role of ErbB receptors and ligands in lung maladaptive remodeling, focusing on IPF.
- To examine cellular pathways and epithelial-mesenchymal interactions in IPF.
- To evaluate ErbB signaling inhibitors in preclinical lung injury models and inform IPF clinical trials.
Main Methods:
- Literature review of ErbB signaling in lung development, physiology, and disease.
- Analysis of pathways contributing to epithelial-mesenchymal miscommunication in IPF.
- Overview of in vivo studies on ErbB signaling inhibitors in lung injury models.
Main Results:
- ErbB signaling pathways are crucial in lung tissue remodeling.
- Epithelial-mesenchymal miscommunication is a key feature of IPF.
- Preclinical studies show potential for ErbB inhibitors in lung injury.
Conclusions:
- Understanding ErbB biology in the lung is essential for treating IPF.
- Insights from cancer treatments using ErbB1 inhibitors can guide IPF clinical trials.
- Targeting ErbB signaling offers a potential therapeutic strategy for IPF.
Keywords:
ErbB-signalingTGF-αTGF-βamphiregulinepidermal growth factorepidermal growth factor receptoridiopathic pulmonary fibrosislung fibrosisneuregulin 1pulmonary fibrosistyrosine kinase inhibitorMore Related Videos
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