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Two-Photon-Near Infrared-II Antimicrobial Graphene-Nanoagent for Ultraviolet-Near Infrared Imaging and
Wen-Shuo Kuo1,2,3, Yen-Sung Lin4,5, Ping-Ching Wu6
1School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing 210044, China.
International Journal of Molecular Sciences
|March 25, 2022
Summary
Nitrogen-doped, amino-functionalized graphene quantum dots (amino-N-GQDs) show enhanced two-photon absorption and luminescence. These materials are effective for in-depth bio-imaging and two-photon photodynamic therapy (PDT) against microbes.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Graphene quantum dots (GQDs) are promising nanomaterials with unique optical properties.
- Chemical modification, including nitrogen doping and amino functionalization, can enhance GQD performance.
- Improving charge transfer efficiency is key to optimizing GQD applications in imaging and therapy.
Purpose of the Study:
- To enhance the two-photon absorption and luminescence properties of GQD-based materials.
- To investigate the potential of modified GQDs for in-depth bio-imaging and photodynamic therapy (PDT).
- To explore the excitation-wavelength-independent near-infrared luminescence and size-dependent properties of modified GQDs.
Main Methods:
- Chemical modification of graphene quantum dots (GQDs) with nitrogen doping and amino functionalization to create amino-N-GQDs.
- Characterization of enhanced two-photon absorption, photoluminescence, and stability.
- Sorting of amino-N-GQDs to achieve excitation-wavelength-independent emission.
- Evaluation of size-dependent photochemical and electrochemical efficacy.
- Assessment of two-photon photodynamic therapy (PDT) efficacy and reactive oxygen species generation.
Main Results:
- Nitrogen doping and amino functionalization significantly enhanced two-photon absorption, TPE stability, TPE cross-sections, and two-photon luminescence.
- Sorted amino-N-GQDs exhibited excitation-wavelength-independent two-photon luminescence in the near-infrared region.
- Increased size led to size-dependent photochemical and electrochemical efficacy, improved photoluminescence quantum yield, and efficient two-photon PDT.
- Generation of reactive oxygen species was observed, indicating potential for PDT.
Conclusions:
- Amino-N-GQDs demonstrate superior two-photon properties suitable for advanced bio-imaging applications.
- The developed materials show significant potential for in-depth imaging and targeted two-photon photodynamic therapy (PDT).
- Sorted amino-N-GQDs offer a versatile platform for combating infectious and multidrug-resistant microbes through PDT.
