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Related Experiment Video

Updated: Sep 29, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Cannabinoids: Therapeutic Use in Clinical Practice.

Cristina Pagano1, Giovanna Navarra1, Laura Coppola1

  • 1Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.

International Journal of Molecular Sciences
|March 25, 2022
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Summary

Cannabinoids from Cannabis sativa show therapeutic potential, with new research minimizing side effects. Approved cannabinoid drugs treat multiple sclerosis, cancer, and AIDS, highlighting their clinical relevance.

Keywords:
cancercannabinoidsneurodegenerative diseasesskin disordersviral infections

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Oncology

Background:

  • Cannabis sativa contains cannabinoids with therapeutic potential, but Δ9-tetrahydrocannabinol (THC) causes psychotropic effects.
  • The endocannabinoid system's discovery offers new therapeutic targets for various disorders, mitigating THC's adverse effects.
  • FDA-approved cannabinoid drugs like nabiximols, dronabinol, and nabilone are used for multiple sclerosis, chemotherapy side effects, and AIDS-related anorexia.

Purpose of the Study:

  • To review the therapeutic efficacy of natural and synthetic cannabinoids.
  • To explore the clinical relevance of cannabinoids in treating diverse diseases.
  • To highlight advancements in cannabinoid-based therapeutics.

Main Methods:

  • Literature review of medical case reports and scientific discoveries.
  • Analysis of FDA-approved cannabinoid drugs and their applications.
  • Examination of research on the endocannabinoid system and its therapeutic targets.

Main Results:

  • Cannabinoids demonstrate efficacy in managing pain and spasticity in multiple sclerosis.
  • Cannabinoids are effective in treating chemotherapy-induced nausea/vomiting and AIDS-related anorexia.
  • Emerging research indicates potential applications in neurodegenerative diseases, dermatological conditions, and viral infections.

Conclusions:

  • Natural and synthetic cannabinoids offer significant therapeutic potential across various medical conditions.
  • Targeting the endocannabinoid system allows for cannabinoid therapies with minimized psychotropic effects.
  • Further research into cannabinoid applications holds promise for novel treatment strategies.