Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

141
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
141
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

67
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
67
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

58
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
58
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

111
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
111
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

59
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
59
Inflammation01:38

Inflammation

55.8K
Overview
55.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ligand preference of LRP1 is regulated by O-glycans.

Science advances·2026
Same author

Regulation of Cell Proliferation and Migration by Extracellular Phosphatidic Acid.

Biomedicines·2026
Same author

Blood proteomics: insights from public data.

Genome biology·2026
Same author

Sequencing and functional characterization of SCARB1 variants in subjects with extreme HDL cholesterol levels.

Journal of clinical lipidology·2026
Same author

Role of Ceramide Kinase/C1P in the Regulation of Cell Growth and Survival.

International journal of molecular sciences·2025
Same author

Lentiviral Vectors: From Wild-Type Viruses to Efficient Multi-Functional Delivery Vectors.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Sep 29, 2025

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.1K

Pathophysiology of Atherosclerosis.

Shifa Jebari-Benslaiman1,2, Unai Galicia-García2,3, Asier Larrea-Sebal2,3

  • 1Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain.

International Journal of Molecular Sciences
|March 25, 2022
PubMed
Summary

Atherosclerosis, a key risk factor for cardiovascular disease (CVD), involves complex stages from endothelial dysfunction to plaque rupture. This review explores its development, microRNA/lncRNA roles, microbiota influence, and sex-based risk factors.

Keywords:
atheroma plaqueatherosclerosisendothelial dysfunctionlncRNAmicroRNAmicrobiotaocLDLrisk factors

More Related Videos

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

38.5K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K

Related Experiment Videos

Last Updated: Sep 29, 2025

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.1K
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

38.5K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Pathology

Background:

  • Atherosclerosis is the primary risk factor for cardiovascular disease (CVD), the leading global cause of mortality.
  • The disease process involves endothelial activation, lipid accumulation, fibrous tissue formation, calcification, and inflammation, leading to atheroma plaque development.
  • These pathological changes result in vessel narrowing and can precipitate cardiovascular complications.

Purpose of the Study:

  • To provide a comprehensive review of atherosclerosis development, from initial endothelial dysfunction to plaque rupture.
  • To explore the post-transcriptional regulation of atheroma plaque by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs).
  • To examine the role of microbiota and the significance of sex as a risk factor in atherosclerosis.

Main Methods:

  • Literature review focusing on the stages of atherosclerosis.
  • Analysis of research on microRNA and lncRNA involvement in atheroma plaque modulation.
  • Synthesis of studies investigating the impact of microbiota and sex on atherosclerosis.

Main Results:

  • Atherosclerosis progresses through distinct stages, initiated by endothelial dysfunction.
  • MicroRNAs and lncRNAs play significant roles in regulating and modulating atheroma plaque formation and progression.
  • Microbiota composition and sex differences are critical factors influencing atherosclerosis development and risk.

Conclusions:

  • Understanding the multifaceted nature of atherosclerosis, including molecular and environmental factors, is crucial for effective disease management.
  • Targeting microRNAs, lncRNAs, and microbiota may offer novel therapeutic strategies for atherosclerosis.
  • Recognizing sex as a key determinant in atherosclerosis risk is essential for personalized prevention and treatment approaches.