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The Sequential Change in Left Ventricular Function among Various Cardiovascular Diseases: A 12-Year Study

Sheng-Nan Chang1, Jou-Wei Lin1, Yi-Chih Wang2

  • 1Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Yun-Lin Branch, Yun-Lin City 640, Taiwan.

Journal of Personalized Medicine
|March 25, 2022
PubMed

Insights

Hypertension patients showed better preserved diastolic function with aging compared to healthy elderly and coronary artery disease patients, despite aggressive treatment. This 12-year study highlights differences in left ventricular diastolic dysfunction progression.

Area of Science:

  • Cardiology
  • Geriatrics
  • Internal Medicine

Background:

  • Longitudinal changes in left ventricular diastolic dysfunction (LVDD) were studied over 12 years.
  • Comparison groups included healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients.

Purpose of the Study:

  • To compare the longitudinal changes in LVDD among healthy elderly, CAD, and HTN patients.
  • To assess the impact of aging on diastolic function in these distinct patient cohorts.

Main Methods:

  • A 12-year observational study (2008-2020) involving 1476 patients and 3181 echocardiograms.
  • Final analysis included 130 participants with over 10 years of follow-up: 36 healthy elderly, 51 CAD, and 43 HTN.
  • Echocardiographic parameters and NYHA functional class were used to assess diastolic function.

Main Results:

  • Significant differences in diastolic function changes were observed between elderly vs. HTN and CAD vs. HTN groups.
  • Septal and lateral E/e′ ratios, integrated score index, and NYHA functional class showed significant variations.
  • Aging increased the integrated score index more in healthy elderly (0.2/year) and CAD (0.15/year) than in HTN patients (0.06/year).

Conclusions:

  • Diastolic function was relatively preserved in HTN patients with aging compared to elderly and CAD subjects, even under aggressive treatment.
  • Hypertension management may play a crucial role in mitigating age-related decline in diastolic function.
  • The findings suggest distinct trajectories of LVDD progression based on underlying cardiovascular conditions.

Keywords:
2-dimensional echocardiographycoronary artery diseasediastolic functionelderlyhypertensionintegrated score indextissue Doppler imaging

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