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Gastrin: From Physiology to Gastrointestinal Malignancies
Suzann Duan1, Karen Rico1, Juanita L Merchant1
1Department of Medicine, Division of Gastroenterology and Hepatology, Arizona Comprehensive Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
Function (Oxford, England)
|March 25, 2022
Summary
Gastrin
Area of Science:
- Gastroenterology and Oncology
- Molecular Biology
- Endocrinology
Background:
- Proton pump inhibitors (PPIs) and Helicobacter pylori infection influence gastrin levels.
- Gastrin's role in gastrointestinal (GI) malignancies is complex, with both tumor-promoting and suppressing effects.
- Pathological gastrin levels are linked to enterochromaffin-like cell hyperplasia and carcinoid tumors.
Approach:
- Review of upstream mediators of gastrin gene regulation.
- Exploration of gastrin's molecular biology in GI cancers.
- Focus on gastrin regulation in neuroendocrine neoplasms.
Key Points:
- Widespread PPI use revisits gastrin's mitogenic actions in GI cancers.
- Gastrin exhibits dichotomous roles in tumorigenesis.
- Inflammation from H. pylori and PPIs are key regulators of gastrin.
Conclusions:
- Understanding gastrin's nuanced roles is crucial for GI cancer research.
- Targeting tissue-specific transcriptional targets of gastrin offers therapeutic potential.
- Further research into gastrin's regulation in neuroendocrine neoplasms is warranted.
Keywords:
G-cellGEP-NETHelicobacter pyloriMEN1gastrinomahypergastrinemianeuroendocrine tumorsomatostatinMore Related Videos
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