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Updated: Sep 29, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
[Perinatal maternal suicide: How to prevent?]
M-N Vacheron1, R Dugravier2, V Tessier3
1Psychiatrie, psychiatrie et neurosciences, GHU Paris, secteur adulte pôle 14, 75014 Paris, France.
Suicide is a leading cause of maternal death in France, accounting for 13.4% of cases. Improved screening, multidisciplinary care, and mental health support are crucial for preventing these tragic deaths.
Area of Science:
- Public Health
- Psychiatry
- Obstetrics & Gynecology
Background:
- Maternal mortality remains a critical public health concern globally.
- The sixth report of the National Confidential Survey on Maternal Deaths in France (2013-2015) provides updated data on causes and preventability.
- Suicide has emerged as a significant, yet often overlooked, cause of maternal death.
Purpose of the Study:
- To analyze the frequency, risk factors, causes, care adequacy, and preventability of maternal deaths in France between 2013 and 2015.
- To specifically investigate the circumstances and contributing factors of maternal suicides.
- To identify key areas for improving care and prevention strategies.
Main Methods:
- Exhaustive identification and confidential analysis of maternal deaths occurring during pregnancy or up to one year postpartum.
- Information collection by volunteer assessors including medical history, pregnancy course, and circumstances of death.
- Review and classification by a National Committee of Experts, including psychiatrists, to determine cause, care adequacy, and preventability.
Main Results:
- Suicide was the second leading cause of maternal death (13.4%), with 35 cases over the triennium.
- Maternal suicides occurred primarily postpartum (77% between 43 days and 1 year after birth).
- Suboptimal care (72% of cases) was linked to lack of multidisciplinary management and poor patient-system interaction, with 91% of preventable deaths attributed to these factors.
Conclusions:
- Suicide is a major preventable cause of maternal mortality, necessitating enhanced mental health screening and support.
- Improved multidisciplinary management, early detection of psychiatric issues, and better coordination between healthcare providers are essential.
- Recommendations include structured psychiatric history screening, early postnatal assessments, and integrated medico-psycho-social support systems.
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