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Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
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In-Hospital Outcomes in Pregnancy After Heart Transplantation
Ersilia M DeFilippis1, Vanessa Blumer2, Robert J Mentz2
1Division of Cardiology, Columbia University Irving Medical Center, New York, New York.
The American Journal of Cardiology
|March 25, 2022
Summary
Pregnancy after heart transplantation (HT) is increasing, but outcomes require more study. Post-HT patients face higher risks for hypertensive disorders and labor induction compared to those without heart failure history.
Area of Science:
- Cardiology
- Obstetrics & Gynecology
- Transplantation Medicine
Background:
- Successful pregnancies in heart transplant (HT) recipients are rising.
- Limited data exists on maternal and fetal outcomes post-delivery in HT patients.
Purpose of the Study:
- To compare adverse delivery events in heart transplant recipients with a control group.
- To identify specific maternal risks associated with pregnancy after heart transplantation.
Main Methods:
- Analysis of Nationwide Inpatient Sample data from 2010-2015.
- Inclusion of delivery hospitalizations for HT recipients and a control group without heart failure history.
- Comparison of demographic, comorbidity, and delivery outcome data.
Main Results:
- Heart transplant recipients had higher comorbidity burden and lower income.
- Post-HT women showed significantly increased incidence of hypertensive disorders of pregnancy (preeclampsia) and labor induction.
- No significant differences were observed in gestational diabetes, C-section rates, fetal growth restriction, malformations, or preterm delivery.
Conclusions:
- Women with a history of heart transplantation experience increased maternal risks, particularly hypertensive disorders and need for labor induction.
- These patients present with greater comorbidity burden.
- Further research is essential to optimize obstetric care and improve maternal-fetal outcomes for the heart transplant population.
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