A Randomized, Placebo-Controlled, Split-Neck Trial of Hyaluronic Acid Filler for Static Horizontal Neck Rhytides...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Cosmetic Surgery

Background:

• Hyaluronic acid (HA) fillers are widely used for facial rejuvenation.
• Limited prospective data exists on HA filler safety and efficacy for neck rejuvenation in the United States.

Purpose of the Study:

• To assess the efficacy and safety of a specific HA filler (Restylane Refyne) for correcting static horizontal neck rhytides.
• To compare the outcomes of using a cannula versus a needle for HA filler injection in the neck.

Main Methods:

• A prospective, randomized trial involving 26 subjects treated with HA filler or saline.
• Injections were administered using both cannula and needle techniques on contralateral sides of the neck.
• Efficacy was evaluated using the Transverse Neck Line Scale, Canfield photography, and Global Aesthetic Improvement Scale.

Main Results:

• Significant improvement in horizontal neck lines was observed 30 days post-treatment compared to saline.
• No significant adverse events were reported.
• Needle injections resulted in significantly greater aesthetic improvement than cannula injections.

Conclusions:

• Restylane Refyne is a safe and effective HA filler for treating static horizontal neck rhytides.
• Both cannula and needle delivery methods are viable, with needles demonstrating superior efficacy.
• Further research may explore optimal techniques for neck rejuvenation with HA fillers.