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Updated: Sep 29, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
Contralateral Forced Eyelid Closure Increases Intraocular Pressure
Samyuktha Melachuri1, Laura Palazzolo, Deepinder K Dhaliwal
1Department of Ophthalmology, (S.M., D.K.D.) University of Pittsburgh Medical Center, Pittsburgh, PA; and Department of Ophthalmology (L.P.), New York University Langone Health, New York, NY.
Objectives:
The purpose of the study was to describe the influence of contralateral forced eyelid closure on intraocular pressure (IOP).
Methods:
Twenty-one healthy volunteers with no ophthalmic history had their IOP measured in the supine position to simulate the intraoperative environment. Intraocular pressure was measured with a handheld tonometer over three scenarios: (1) both eyes in a relaxed state, (2) eyelid speculum in the right eye with both eyes open and relaxed, (3) eyelid speculum in the right eye with the fellow eye squeezing tightly.
Results:
Intraocular pressure significantly increased with forced contralateral eyelid squeezing compared with the relaxed state by a mean of 7.71±5.08 mm Hg (95% Confidence Interval of 5.40-7.37), P<0.001.
Conclusions:
Contralateral eyelid squeezing can significantly increase intraoperative IOP measurements.
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