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Liposomes as Tools to Improve Therapeutic Enzyme Performance
Maria Eugénia Meirinhos Cruz1, Maria Luísa Corvo1, Maria Bárbara Martins1
1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Pharmaceutics
|March 26, 2022
Summary
Enzymes are increasingly used as therapeutics, but face delivery challenges. Nanotechnology, particularly liposomes, offers solutions to improve enzyme drug efficacy and reduce side effects.
Area of Science:
- Biopharmaceuticals
- Nanotechnology in Drug Delivery
- Enzyme Therapeutics
Background:
- The definition of drugs has expanded to include macromolecules like proteins and enzymes.
- Enzymes offer therapeutic potential but require advanced delivery systems.
- Challenges include immunogenicity and short circulation times for enzyme drugs.
Purpose of the Study:
- To review therapeutic enzymes and their applications.
- To discuss challenges in enzyme drug delivery.
- To explore nanotechnological strategies, focusing on liposomes, for enzyme delivery.
Main Methods:
- Literature review of therapeutic enzymes and drug delivery systems.
- Focus on nanocarriers, especially liposomes, for enzyme delivery.
- Discussion of preclinical data for liposomal enzyme formulations.
Main Results:
- Several enzymes have reached the pharmaceutical market.
- Liposomes are a well-studied nanosystem for in vivo enzyme delivery.
- Preclinical studies show successful results for liposomal L-Asparaginase and Superoxide Dismutase.
Conclusions:
- Nanotechnology, particularly liposomes, can overcome limitations of enzyme therapeutics.
- Liposomal formulations enhance enzyme stability, circulation time, and reduce immunogenicity.
- Further development of liposomal enzyme formulations holds promise for improved patient outcomes.
