Related Experiment Video

Updated: Sep 29, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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Microbiota, IgA and Multiple Sclerosis

Léo Boussamet1, Muhammad Shahid Riaz Rajoka2, Laureline Berthelot1

  • 1Centre for Research in Transplantation and Translation Immunology, Nantes Université, Inserm, CR2TI UMR, 1064 Nantes, France.

Microorganisms
|March 26, 2022
PubMed

Insights

Multiple sclerosis (MS) involves gut bacteria and immune cells. IgA+ plasma cells producing IL-10 may regulate gut microbiota, offering new insights into neuroinflammation in MS.

Area of Science:

  • Neuroimmunology
  • Microbiome research
  • Autoimmune diseases

Background:

  • Multiple sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system.
  • Gut microbiota alterations are observed in MS patients, influencing disease severity.
  • B cells play a role in MS pathology, but their precise function, especially plasma cells, is complex.

Purpose of the Study:

  • To review the interaction between immunoglobulin A (IgA), gut microbiota, and IgA+ B cells in MS.
  • To explore the regulatory role of IgA+ plasma cells in MS pathogenesis.
  • To highlight novel pathways in neuroinflammation regulation.

Main Methods:

  • Literature review focusing on IgA, gut microbiota, and B cells in MS.
  • Analysis of studies on microbiota transplantation and B cell depletion therapies.
  • Examination of mechanisms involving IgA+ plasma cells and IL-10 production.

Main Results:

  • Gut microbiota composition is altered in MS patients.
  • IgA+ plasma cells producing IL-10, specific for gut microbiota, may have a regulatory role.
  • IgA coating of bacteria is modified in the gut of MS patients.

Conclusions:

  • IgA interactions with gut microbiota and IgA+ B cells represent a significant pathway in MS neuroinflammation.
  • Understanding these interactions may reveal new therapeutic targets for MS.
  • The role of plasma cells in MS warrants further investigation, particularly their immunomodulatory functions.
Keywords:
IL-10IgAgut microbiotamultiple sclerosisneuroinflammationregulation

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