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Updated: Sep 29, 2025

Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings

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Next-Generation Sequencing for Confronting Virus Pandemics.

Josep Quer^1,2,3, Sergi Colomer-Castell^1,2, Carolina Campos^1,2

¹Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institut of Research (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

|March 26, 2022

Summary

This summary is machine-generated.

Virus pandemics are a recurring threat, accelerated by increased human-animal interaction. Next-generation sequencing (NGS) offers crucial tools for early detection, vaccine development, and understanding viral transmission to mitigate future outbreaks.

Keywords:

COVID-19 NGS SARS-CoV-2 deep-sequencing diagnostic tools pandemics variability viruses zoonosis

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Published on: July 2, 2016

Area of Science:

Virology
Epidemiology
Genomics

Background:

Virus pandemics are recurrent global health threats.
Increased human-animal interaction and global travel accelerate zoonotic viral spillover.
Pandemic control relies on knowledge-based interventions rather than physical barriers.

Purpose of the Study:

To highlight the accelerating rate of zoonotic viral spillover.
To emphasize the critical role of genetic detection and characterization in pandemic preparedness.
To showcase the multifaceted applications of next-generation sequencing (NGS) in combating viral threats.

Main Methods:

Utilizing next-generation sequencing (NGS) for genetic detection, identification, and characterization of infectious agents.
Developing rapid molecular assays, such as PCR-based tests.
Leveraging genomic data for vaccine and antiviral drug development.

Main Results:

NGS enables rapid development of diagnostic assays and vaccines (mRNA, DNA).
Genomic analysis aids in identifying outbreaks, transmission dynamics, and spillover events.
NGS facilitates detection of new variants, vaccine resistance, and novel transmission routes.

Conclusions:

NGS is an indispensable tool for pandemic prevention and response.
Understanding viral genetics is key to developing effective countermeasures.
Proactive genomic surveillance is essential for mitigating the impact of future viral pandemics.