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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Inflammation01:38

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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

62
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Related Experiment Video

Updated: Sep 29, 2025

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
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Circular RNAs in atherosclerosis.

Xiaoni Huang1, Yuwen Zhao1, Huijiao Zhou1

  • 1Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou City, Guangdong Province 510630, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 27, 2022
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) show promise as biomarkers for atherosclerosis (AS), a major cause of cardiovascular disease. Research highlights their diagnostic potential and therapeutic roles in managing AS.

Keywords:
AtherosclerosisBiomarkerCardiovascular diseaseCircRNACircular RNA

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Atherosclerosis (AS) is a chronic inflammatory arterial disease and a leading cause of mortality.
  • Cardiovascular diseases linked to AS pose a significant global health burden.

Purpose of the Study:

  • To review the biogenesis, classification, and functions of circular RNAs (circRNAs).
  • To summarize current research on circRNAs as diagnostic biomarkers for AS.
  • To explore the regulatory role of circRNAs in AS pathogenesis and their therapeutic potential.

Main Methods:

  • Literature review of studies on circRNAs and atherosclerosis.
  • Analysis of circRNA biogenesis, function, and classification.
  • Synthesis of research findings on circRNAs in AS diagnosis and therapy.

Main Results:

  • CircRNAs are endogenous non-coding RNAs with unique structures.
  • Evidence suggests circRNAs can serve as reliable biomarkers for AS diagnosis.
  • CircRNAs play regulatory roles in AS development and offer therapeutic avenues.

Conclusions:

  • CircRNAs represent a novel class of biomarkers for atherosclerosis.
  • Understanding circRNA functions is crucial for developing new diagnostic and therapeutic strategies for AS.
  • Further research into circRNAs could significantly advance cardiovascular disease management.