Polysaccharides, as biological macromolecule-based scaffolding biomaterials in cornea tissue engineering: A review

Corneal-related diseases and injuries are the leading causes of vision loss, estimated to affect over 10 million people worldwide. Currently, cadaveric corneal grafts are considered the gold standard of treatment to restore cornea-related vision. However, this treatment modality faces different challenges such as donor shortage and graft failure. Therefore, the need for alternative solutions continues to grow. Tissue engineering has dramatically progressed to produce artificial cornea implants in order to repair, regenerate, or replace the damaged cornea. In this regard, a variety of polysaccharides such as cellulose, chitosan, alginate, agarose, and hyaluronic acid have been widely explored as scaffolding biomaterials for the production of tissue-engineered cornea. These polymers are known for their excellent biocompatibility, versatile properties, and processability. Recent progress and future perspectives of polysaccharide-based biomaterials in cornea tissue engineering is reviewed here.