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Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Inhibitory control as a potential treatment target for obesity.

M T de Klerk^1,2, P A M Smeets^1,3, S E la Fleur²

¹Image Sciences Institute, UMC Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.

Nutritional Neuroscience

|March 28, 2022

Summary

Inhibitory control, crucial for regulating food intake, is impaired in obesity. Targeting this cognitive function shows promise for weight loss interventions, though significant weight reduction remains challenging.

Keywords:

Obesity inhibitory brain areas inhibitory control interventions weight loss

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Area of Science:

Neuroscience and Psychology of Obesity
Cognitive Control and Eating Behavior

Background:

Obesity is linked to heightened reward sensitivity towards food and deficient inhibitory control.
Understanding the role of inhibitory control in obesity is critical for developing effective weight management strategies.

Approach:

A narrative review synthesizing findings from 41 studies identified through comprehensive literature searches (PubMed, Web of Science, Google Scholar) up to May 2021.
Analysis focused on the relationship between inhibitory control, obesity, and weight loss outcomes, including intervention effectiveness.

Key Points:

Individuals with obesity exhibit poorer food-specific inhibitory control, especially when hungry, correlating with reduced activation in key brain inhibitory areas.
Impaired inhibitory control predicts future weight gain, while enhanced activation of these brain regions is associated with successful weight loss and maintenance.
Interventions like inhibitory control training and neuromodulation (rTMS, tDCS) show potential, with some success in reducing food desire and promoting weight loss, though results vary.

Conclusions:

Inhibitory control is a significant factor in obesity.
Targeting inhibitory control presents a viable avenue for weight loss interventions, although achieving substantial and consistent weight loss requires further refinement of these approaches.