Copper-Catalyzed anti-Selective Radical 1,2-Alkylarylation of Terminal Alkynes
Jun-Bin Tang1,2,3, Jun-Qian Bian3, Yu-Shuai Zhang3
1College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518071, China.
Abstract:
A copper-catalyzed highly anti-selective radical 1,2-alkylarylation of terminal alkynes with aryl boronic acids and alkyl bromides has been established. The reaction exhibits high compatibility with a wide range of terminal alkynes and diverse aryl boronic acids, thus providing facile access to various stereodefined trisubstituted alkenes in high yield under mild reaction conditions. Preliminary mechanistic investigations support the formation of alkyl radicals and their subsequent addition to alkynes in the reaction.
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