A cloth-based electrochemiluminescence sensor for determination of salbutamol residues in pork samples

The fabrication of a cloth-based analytical device combined with electrochemiluminescence detection was established for the rapid determination of salbutamol in pork samples. A hand-coloring method to pattern the hydrophobic chamber was employed, and a three-carbon electrode system was subsequently screen printed onto the patterned cotton chamber. Further modifications of the working electrode surface were conducted using platinum nanoparticles and chitosan solution. The salbutamol enhanced the electrochemiluminescence signal of tris(2,2'-bipyridyl)ruthenium(II) complex in the Britton-Robinson buffer of pH 9.5 and the potential quantitative assay for SAL detection was exhibited. The proposed sensor illustrated a linear calibration curve of the logarithmic SAL concentration in the range of 5 × 10^-2 to 5 × 10⁴ µg L^-1 (r² > 0.996). A limit of detection of 6.8 ng L^-1 was observed. The CAD-ECL sensor was successfully applied for the determination of salbutamol residuals in pork samples. The method validation was performed using the LC-MS method.