Development of the PhysioVessel: a customizable platform for simulating physiological fluid resuscitation.

Area of Science:

• Biomedical Engineering
• Critical Care Medicine
• Trauma Research

Background:

• Uncontrolled hemorrhage is a primary cause of death in trauma.
• Automated resuscitation solutions can improve trauma patient outcomes.
• Developing these solutions often requires extensive animal studies.

Purpose of the Study:

• To present a tabletop model for high-throughput testing of fluid resuscitation.
• To enable development of automated critical care interventions.
• To reduce reliance on large animal datasets.

Main Methods:

• A design approach using curve-fitting, 3D modeling, and fabrication of a fluid reservoir.
• Application to pressure-volume datasets from porcine hemorrhage studies.
• Evaluation using whole blood and crystalloid resuscitation scenarios.

Main Results:

• The fabricated fluid reservoirs accurately mimicked physiological pressure-volume data.
• Normalized pressure-volume curves were reproduced within one standard deviation of porcine data.
• Mean residual differences were 0.018 for whole blood and 0.016 for crystalloid.

Conclusions:

• The presented design process is effective for creating physiologically relevant models.
• This platform simplifies initial testing of resuscitation technologies.
• It aids in developing closed-loop algorithms for automated resuscitation.