Philosophy of new drug discovery

Lactacystin increases LDL receptor level on HepG2 cells.

Biochemical and biophysical research communications·1996

Proteasome-dependent regulation of p21WAF1/CIP1 expression.

Biochemical and biophysical research communications·1996

Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.

The Journal of biological chemistry·1996

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity.

The Journal of biological chemistry·1996

Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.

The Journal of antibiotics·1996

Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity.

The Journal of antibiotics·1996

T helper cell activation and human retroviral pathogenesis.

Microbiological reviews·1996

The secretory pathway of protists: spatial and functional organization and evolution.

Microbiological reviews·1996

Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses.

Microbiological reviews·1996

Soil microorganisms as controllers of atmospheric trace gases (H2, CO, CH4, OCS, N2O, and NO).

Microbiological reviews·1996

Proton-dependent multidrug efflux systems.

Microbiological reviews·1996

Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

Microbiological reviews·1996

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling.

Molecular therapy. Nucleic acids·2026

Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD.

Bioorganic & medicinal chemistry letters·2026

A Pyrazole-Amide-Azobenzene scaffold for the photocontrollable modulation of succinate dehydrogenase: synthesis, photophysical and biological properties.

Bioorganic chemistry·2026

Mechanistic insights into Ginkgo biloba leaves against cisplatin-induced ototoxicity: An approach combining network pharmacology and computer simulation.

Computational biology and chemistry·2026

In silico pharmacological evaluation of a multi-epitope vaccine candidate targeting the G1 and G2 glycoproteins of Oropouche virus via TLR3 interaction.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Network-guided Evaluation of β-sitosterol in Inflammatory and Profibrotic Mesangial-Cell Models Relevant to Chronic Glomerulonephritis.

Journal of visualized experiments : JoVE·2026

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Philosophy of new drug discovery

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Lactacystin increases LDL receptor level on HepG2 cells.

Proteasome-dependent regulation of p21WAF1/CIP1 expression.

Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity.

Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.

Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity.

T helper cell activation and human retroviral pathogenesis.

The secretory pathway of protists: spatial and functional organization and evolution.

Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses.

Soil microorganisms as controllers of atmospheric trace gases (H2, CO, CH4, OCS, N2O, and NO).

Proton-dependent multidrug efflux systems.

Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling.

Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD.

A Pyrazole-Amide-Azobenzene scaffold for the photocontrollable modulation of succinate dehydrogenase: synthesis, photophysical and biological properties.

Mechanistic insights into Ginkgo biloba leaves against cisplatin-induced ototoxicity: An approach combining network pharmacology and computer simulation.

In silico pharmacological evaluation of a multi-epitope vaccine candidate targeting the G1 and G2 glycoproteins of Oropouche virus via TLR3 interaction.

Network-guided Evaluation of β-sitosterol in Inflammatory and Profibrotic Mesangial-Cell Models Relevant to Chronic Glomerulonephritis.

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Philosophy of new drug discovery

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