Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Regulation01:25

Drug Regulation

1.9K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.9K
Global Regulatory Systems01:28

Global Regulatory Systems

99
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
99
Applications of RC Circuits01:22

Applications of RC Circuits

3.5K
A relaxation oscillator is one of the applications of RC circuits. A neon lamp relaxation oscillator comprises a capacitor, a resistor, a voltage source, and a lamp. The lamp acts like an open circuit, with infinite resistance until the potential difference across the lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit with zero resistance, and the capacitor discharges through the lamp, thus producing light. Once the capacitor is fully discharged through the...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidencing strain-dependency of metabolic pathways within 1,494 lactic bacteria genomes with the <i>in silico</i> screening Prolipipe pipeline.

PeerJ·2026
Same author

CDO1 is a new biomarker to discriminate aggressive forms of prostate cancer.

Oncogene·2026
Same author

A subset of histamine H4 receptor antagonists prevents B lymphocyte proliferation induced by BCR/TLR9 engagement or EBV infection.

Antiviral research·2026
Same author

Reduced glutathione levels in <i>Enterococcus faecalis</i> trigger metabolic and transcriptional compensatory adjustments during iron exposure.

mSystems·2025
Same author

Modeling the emergent metabolic potential of soil microbiomes in Atacama landscapes.

Environmental microbiome·2025
Same author

Evolutionary history and association with seaweeds shape the genomes and metabolisms of marine bacteria.

mSphere·2025

Related Experiment Video

Updated: Sep 28, 2025

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.4K

Improving reusability along the data life cycle: a regulatory circuits case study.

Marine Louarn1,2, Fabrice Chatonnet3,4, Xavier Garnier5

  • 1Univ Rennes, CNRS, Inria, IRISA, UMR 6074, Rennes, F-35000, France. marine.louarn@inria.fr.

Journal of Biomedical Semantics
|March 29, 2022
PubMed
Summary

We developed Linked Extended Regulatory Circuits (LERC), a modular RDF dataset for human cell genomics data. LERC enhances data reuse and integration for transcription factor-gene interaction networks.

Keywords:
BioinformaticsDataset architectureLinked Open DataRDF named graphsReusabilitySPARQL

More Related Videos

Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

1.7K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.5K

Related Experiment Videos

Last Updated: Sep 28, 2025

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.4K
Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

1.7K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.5K

Area of Science:

  • Life sciences
  • Genomics
  • Bioinformatics

Background:

  • Standardization of life science data is challenging due to non-standard formats.
  • The Regulatory Circuits project integrates human cell genomics data but faces limitations in reuse and extension.
  • Existing RDF triplestore integration lacked network storage and metadata, hindering data accessibility.

Purpose of the Study:

  • To create a flexible and reusable representation of the Regulatory Circuits dataset using Semantic Web technologies.
  • To address limitations in data update, reuse, and extension of existing genomics datasets.
  • To facilitate integration and enrichment of human cell genomics data.

Main Methods:

  • Developed a modular RDF representation named Linked Extended Regulatory Circuits (LERC).
  • Organized LERC into 1,205 RDF named graphs for biological data, sample/tissue-specific networks, and metadata.
  • Integrated descriptions of biological/experimental context, TF-gene interactions at sample/tissue levels, and metadata.

Main Results:

  • LERC provides a modular RDF representation of the Regulatory Circuits dataset.
  • Contains annotations for TF-gene interactions at sample (808) and tissue (394) levels.
  • Includes 3,910,794,050 triples and is accessible via a SPARQL endpoint.

Conclusions:

  • LERC's modular architecture supports biologically-relevant SPARQL queries.
  • Facilitates easy and fast querying of Regulatory Circuits data.
  • Enhances the reuse of genomics datasets in other studies.