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Association of Matrix Metallopeptidase-2 Genotypes With Risk of Gastric Cancer in Taiwan
Chun-Kai Fu1,2,3,4, Mei-Chin Mong5, Chien-Chih Yu3
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Background/Aim:
Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals.
Materials And Methods:
This study included 121 GC cases and 363 age- and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism.
Results:
The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk.
Conclusion:
The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.
Insights
Matrix metalloproteinase-2 (MMP-2) rs243865 genotypes are linked to reduced gastric cancer risk in Taiwanese individuals. These MMP-2 genotypes may predict susceptibility, especially when combined with lifestyle and infection factors.
Area of Science:
- Genetics
- Oncology
- Biochemistry
Background:
- Matrix metalloproteinase-2 (MMP-2) is crucial for extracellular matrix regulation.
- MMP-2 genotypes' role in gastric cancer (GC) risk remains underexplored.
- Genetic variations in MMP-2 may influence gastric cancer susceptibility.
Purpose of the Study:
- Investigate the association between MMP-2 promoter genotypes (-1306 rs243865 and -735 rs2285053) and GC risk.
- Determine if MMP-2 genotypes contribute to personal susceptibility to GC in a Taiwanese cohort.
- Identify potential genetic markers for predicting GC risk.
Main Methods:
- Case-control study involving 121 GC cases and 363 controls.
- Genotyping of MMP-2 promoter variants (rs243865 and rs2285053) using polymerase chain reaction-restriction fragment length polymorphism.
- Analysis of genotypic and allelic frequencies and stratification by risk factors.
Main Results:
- MMP-2 rs243865 variant genotypes were associated with a decreased risk of GC.
- MMP-2 rs243865 genotypes showed interactions with smoking, alcohol consumption, and H. pylori infection in relation to GC risk.
- No significant association was found between MMP-2 rs2285053 genotype and GC risk.
Conclusions:
- MMP-2 rs243865 genotypes may serve as a novel predictive marker for gastric cancer susceptibility.
- Genetic variations in MMP-2, particularly rs243865, play a role in individual susceptibility to GC.
- Further research is warranted to validate MMP-2 rs243865 as a predictive biomarker for gastric cancer.
