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Updated: Sep 28, 2025
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Poly(Alkyloxyethylene-Lactate Phosphate) for Delivery of Doxorubicin: Synthesis and Characterization
Kanji Yoshikawa1, Teruki Nii1,2,3, Kolio Troev4,5
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Background/Aim:
Serious side effects are associated with the use of doxorubicin. Nanoparticles as carriers for anticancer drugs are useful for reducing side effects and improving therapeutic effects. In this study, a polymer for preparing doxorubicin-containing nanoparticles was developed. Using a novel strategy, a biodegradable poly(oxyethylene glycol lactate H-phosphonate) based on dimethyl H-phosphonate and poly(ethylene glycol)-lactate (PEG-lactate) was synthesized.
Materials And Methods:
Poly(hexadecanyloxyethylene - lactate phosphate) was obtained via chlorination of poly(oxyethylene glycol - lactate H-phosphonate) with trichloroisocyanuric acid and the addition of 1-hexadecanol. The polymer was characterized by 1H NMR and 31P NMR.
Results:
The results of 1H NMR and 31P NMR showed that the polymer was successfully synthesized, and the yield was 46.9%.
Conclusion:
Poly(hexadecanyloxyethylene - lactate phosphate) has potential as a drug carrier.
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