Related Experiment Video
Updated: Sep 28, 2025
06:36
Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
Published on: March 14, 2025
396
Microbial differences between active and remission peri-implantitis.
Yuhei Hashimoto1, Shinsuke Okada2, Keisuke Yasuda3
1Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. hash588@hiroshima-u.ac.jp.
Scientific Reports
|March 29, 2022
Summary
Peri-implantitis, a common cause of dental implant loss, differs microbiologically between active and remission states. Active peri-implantitis shows more periodontal pathogens, while remission is linked to lactic acid bacteria.
Area of Science:
- Oral microbiology
- Periodontology
- Biomaterials science
Background:
- Peri-implantitis is a polymicrobial condition leading to dental implant failure.
- Current prevention and treatment protocols are not universally effective, with some cases progressing rapidly.
- Differentiating between active and resolving peri-implantitis is crucial for targeted management.
Purpose of the Study:
- To investigate the distinct microbial profiles associated with active versus remission peri-implantitis.
- To identify potential microbial biomarkers for differentiating disease states.
Main Methods:
- Subjects (n=20) with peri-implantitis were categorized into active and remission groups.
- Microbiome analysis was performed using 16S rRNA gene pyrosequencing.
- Linear discriminant analysis effect size (LEfSe) was employed to identify differentially abundant taxa.
Main Results:
- The active peri-implantitis group showed higher abundance of periodontal pathogens, including Porphyromonas, Fusobacterium, Treponema, and Tannerella.
- The remission group exhibited a greater presence of lactic acid bacteria, specifically Lactobacillales and Bifidobacterium.
- Distinct microbial signatures were identified between the two clinical states.
Conclusions:
- The microbiome composition significantly differs between active and remission peri-implantitis.
- Periodontal pathogens are associated with active disease, while lactic acid bacteria may indicate a healthier peri-implant state.
- These findings could aid in differentiating peri-implantitis progression and guiding treatment strategies.
