Mathematical modelling of oxygenation under veno-venous ECMO configuration using either a femoral or a bicaval...

The bicaval drainage under veno-venous extracorporeal membrane oxygenation (VV ECMO) was compared in present experimental study to the inferior caval drainage in terms of systemic oxygenation.

Two mathematical models were built to simulate the inferior vena cava-to-right atrium (IVC → RA) route and the bicaval drainage-to-right atrium return (IVC + SVC → RA) route using the following parameters: cardiac output (Q_C), IVC flow/Q_C ratio, venous oxygen saturation, extracorporeal pump flow (Q_EC), and pulmonary shunt (PULM-Shunt) to obtain pulmonary artery oxygen saturation (S_PAO₂) and systemic blood oxygen saturation (SaO₂).

With the IVC → RA route, S_PAO₂ and SaO₂ increased linearly with Q_EC/Q_C until the threshold of the IVC flow/Q_C ratio, beyond which the increase in S_PAO₂ reached a plateau. With the IVC + SVC → RA route, S_PAO₂ and SaO₂ increased linearly with Q_EC/Q_C until 100% with Q_EC/Q_C = 1. The difference in required Q_EC/Q_C between the two routes was all the higher as SaO₂ target or PULM-Shunt were high, and occurred all the earlier as PULM-Shunt were high. The required Q_EC between the two routes could differ from 1.0 L/min (Q_C = 5 L/min) to 1.5 L/min (Q_C = 8 L/min) for SaO₂ target = 90%. Corresponding differences of Q_EC for SaO₂ target = 94% were 4.7 L/min and 7.9 L/min, respectively.

Bicaval drainage under ECMO via the IVC + SVC → RA route gave a superior systemic oxygenation performance when both Q_EC/Q_C and pulmonary shunt were high. The VV-V ECMO configuration (IVC + SVC → RA route) might be an attractive rescue strategy in case of refractory hypoxaemia under VV ECMO.