Modelling neuron fiber interaction and coupling in non-myelinated bundled fiber

Understanding the local dynamics of a neural network relies heavily on local field potential and cell-field interaction. But it is still unclear how local the local potential is and what kinds of consequences the trans-membrane current flow and produced electric field have on the local neural fiber. Mimicking signal transmission in neighboring nerve fiber, a simulation model is built to analyze local behavior due to trans-membrane current, cell-field interactions, and their repercussions on the bundled fiber system. Simulation studies reveal that depending on the coupling parameters, activity in one fiber can depolarize or hyper-polarize adjacent fibers. The suggested cell-field interaction model was tested using an orientation-selective coupled retinal ganglion cell network, which was compared to its uncoupled counterpart. The proposed work has been used to model and simulate local signal dynamics in a bundled fiber system of an orientation-selective RGC network due to cell-field interaction, as well as to gain insight into the possible significance of dendritic fiber coupling in orientation selectivity bandwidth adjustment.