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Related Experiment Video

Updated: Sep 28, 2025

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
07:50

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording

Published on: October 29, 2021

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An open-source transparent microelectrode array.

Isaac A Weaver1, Austin W Li1, Brenda C Shields1

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.

Journal of Neural Engineering
|March 29, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces an accessible, open-source transparent micro-electrode array (MEA) for simultaneous electrical and optical recordings. This technology enables advanced neuroscience research by integrating with standard inverted microscopes.

Keywords:
electrophysiologyglass indium tin oxide (ITO) electrodesopen sourceoptogeneticsphotometryprinted circuit board pre-amplifiertransparent multi-electrode array

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Cell Biology

Background:

  • Micro-electrode arrays (MEAs) are crucial for studying electrically active cells like neurons and myocytes.
  • Traditional MEAs are opaque, limiting their use with optical microscopy techniques.
  • Commercially available transparent MEAs are costly and complex to fabricate.

Purpose of the Study:

  • To develop an open-source, cost-effective transparent micro-electrode array (MEA).
  • To enable simultaneous electrical and optical recordings in cell-based assays.
  • To provide an accessible platform for neuroscience research.

Main Methods:

  • Development of an open-source transparent MEA based on the OpenEphys platform.
  • Integration with Intan Technologies headstage using low-noise connectors.
  • Design of a mechanically stable adaptor for 24-well plate compatibility.

Main Results:

  • Demonstrated performance of the transparent MEA in a multiplexed electrical and optogenetic assay.
  • Successful recording from primary rat hippocampal neurons.
  • Validation of the platform's compatibility with inverted microscopes.

Conclusions:

  • The open-source transparent MEA offers an accessible solution for advanced neuroscience research.
  • The platform requires minimal fabrication or circuit design expertise.
  • Facilitates integrated electrophysiological and optical interrogation of excitable cells.