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Effect of glucocorticoid therapy on long-term growth and development of children with bronchiolitis

Zha-Yidan Aili1, Abulaiti Abuduhaer1

  • 1Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|March 30, 2022
PubMed

Insights

Glucocorticoid therapy for bronchiolitis in children may lead to long-term growth issues. Studies show increased rates of growth retardation and obesity after treatment, particularly with longer durations.

Area of Science:

  • Pediatric Pulmonology
  • Endocrinology
  • Child Development

Background:

  • Bronchiolitis is a common respiratory infection in infants and young children.
  • Glucocorticoids are sometimes used to manage bronchiolitis, but their long-term effects on growth are not fully understood.

Purpose of the Study:

  • To investigate the impact of glucocorticoid therapy on the growth and development of children diagnosed with bronchiolitis.

Main Methods:

  • Retrospective analysis of 143 children with bronchiolitis treated with glucocorticoids.
  • Collected data included initial physical measurements and treatment details.
  • Assessed physical development indices, growth (Z-score), and hematological parameters (osteocalcin, serum phosphorus, IGF-1) after three years.

Main Results:

  • Significant increases in growth retardation and obesity incidence were observed after three years of glucocorticoid therapy (P<0.05).
  • Longer glucocorticoid treatment (≥29 days) correlated with higher obesity rates (P<0.05).
  • Nebulized glucocorticoid treatment showed no significant impact on growth and development (P>0.05).

Conclusions:

  • Glucocorticoid therapy can negatively impact the long-term growth and development of children with bronchiolitis.
  • Elevated serum phosphorus and insulin-like growth factor-1 levels were associated with normal development.
Abstract

Keywords:
BronchiolitisChildGlucocorticoidGrowth and development

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