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Change in intestinal flora after treatment in children with focal epilepsy

Shuai-Zheng Gong1, Jun Qiu, Li-Wen Wu

  • 1Department of Hematology and Oncology, Hunan Children's Hospital, Changsha 410007, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|March 30, 2022
PubMed

Insights

Children with focal epilepsy show altered gut bacteria, with levels normalizing after oxcarbazepine treatment. This epilepsy treatment improves both seizures and intestinal flora balance.

Area of Science:

  • Microbiology
  • Pediatric Neurology
  • Gastroenterology

Background:

  • Intestinal flora dysbiosis is increasingly linked to neurological disorders.
  • Focal epilepsy in children may be associated with specific gut microbiome alterations.

Purpose of the Study:

  • To investigate differences in gut microbiota between children with focal epilepsy and healthy controls.
  • To assess the impact of oxcarbazepine treatment on the gut microbiome in pediatric focal epilepsy.

Main Methods:

  • 16S rDNA sequencing of fecal DNA from 10 children with focal epilepsy (before and after 3 months of oxcarbazepine treatment) and 14 healthy controls.
  • Bioinformatics analysis to compare microbial composition between groups and over time.
  • Clinical data on seizure frequency reduction were recorded.

Main Results:

  • Children with focal epilepsy exhibited significantly higher abundances of Actinobacteria, Escherichia/Shigella, Streptococcus, Collinsella, and Megamonas compared to controls.
  • Oxcarbazepine treatment, reducing seizure frequency by over 50%, led to a significant decrease in these bacterial groups.
  • Significant changes in gut flora were observed after 3 months of treatment.

Conclusions:

  • Focal epilepsy in children is associated with distinct gut microbial profiles.
  • Oxcarbazepine treatment demonstrates efficacy in improving both clinical symptoms and gut microbiome composition in pediatric focal epilepsy.
Abstract

Keywords:
ChildEpilepsyFocal seizureIntestinal flora

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