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Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a
Georg Schett1, Matthew J Loza2, Arumugam Palanichamy2
1Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany. georg.schett@uk-erlangen.de.
Rheumatology and Therapy
|March 30, 2022
Summary
Guselkumab treatment reduced elevated collagen biomarkers in psoriatic arthritis (PsA) patients. C1M levels in guselkumab responders indicate its potential as a biomarker for joint symptom improvement in PsA.
Area of Science:
- Biochemistry
- Immunology
- Rheumatology
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory disease with diverse manifestations.
- Guselkumab, an interleukin-23p19 subunit inhibitor, shows efficacy in treating PsA.
- Extracellular matrix (ECM) biomarkers reflect disease processes in PsA.
Purpose of the Study:
- To evaluate serum ECM biomarker concentrations in PsA patients.
- To assess the relationship between these biomarkers and PsA characteristics.
- To explore the association of biomarkers with clinical response to guselkumab.
Main Methods:
- Serum samples from 260 biologic-naïve PsA patients in the DISCOVER-2 trial were analyzed.
- Samples were collected at baseline and weeks 4, 24, and 52 during guselkumab treatment.
- Biomarkers for collagen degradation (C1M, C3M, C4M, C6M) and formation (PRO-C3, PRO-C6) were measured.
Main Results:
- PsA patients exhibited significantly higher baseline levels of collagen degradation biomarkers (C1M, C3M, C4M, C6M) compared to healthy controls.
- Guselkumab treatment led to a decline in serum C1M, C3M, C4M, and C6M levels.
- Patients achieving ACR20 response had lower baseline C1M levels than non-responders.
Conclusions:
- Serum collagen biomarkers are elevated in PsA patients and decrease with guselkumab treatment.
- C1M is identified as a potential biomarker associated with improved joint signs and symptoms in PsA.
- These findings highlight the role of ECM remodeling in PsA and guselkumab's impact.
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