Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

alpha-Methyldopa for climacteric hot flushes. A double-blind, randomized, cross-over study.

O Andersen, T Engebretsen, V M Solberg

Acta Obstetricia Et Gynecologica Scandinavica

|January 1, 1986

Summary

Single evening doses of alpha-methyldopa may effectively reduce the severity of menopausal hot flushes. While patient preference favored alpha-methyldopa, further research is needed to confirm its efficacy compared to other regimens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Appetite stimulation with cannabis-based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol.

Basic & clinical pharmacology & toxicology·2023

Same author

Effectiveness of first generation disease-modifying therapy to prevent conversion to secondary progressive multiple sclerosis.

Multiple sclerosis and related disorders·2022

Same author

Short-term prediction of secondary progression in a sliding window: A test of a predicting algorithm in a validation cohort.

Multiple sclerosis journal - experimental, translational and clinical·2022

Same author

Epstein-Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis.

European journal of neurology·2020

Same author

Significance of progesterone receptors (PR-A and PR-B) expression as predictors for relapse after successful therapy of endometrial hyperplasia: a retrospective cohort study.

BJOG : an international journal of obstetrics and gynaecology·2018

Same author

Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study.

Acta neurologica Scandinavica·2018

Area of Science:

Obstetrics and Gynecology
Pharmacology

Background:

Menopausal hot flushes are a common symptom affecting many women.
Existing treatments for hot flushes have varying efficacy and side effect profiles.

Purpose of the Study:

To evaluate the efficacy of single evening doses of alpha-methyldopa in managing climacteric hot flushes.
To compare patient preference for alpha-methyldopa versus placebo.

Main Methods:

A double-blind, randomized, cross-over study was conducted.
40 women experiencing climacteric hot flushes participated.
24 participants completed the study, assessing treatment preference, hot flush severity, and frequency.

Main Results:

15 out of 24 completers preferred alpha-methyldopa (p > 0.05).

Related Experiment Videos

Alpha-methyldopa significantly reduced hot flush severity (p < 0.05).

No significant difference was found in hot flush frequency (p > 0.05).

Conclusions:

Single evening doses of alpha-methyldopa show potential efficacy in treating climacteric hot flushes, particularly in reducing severity.
Further investigation is warranted to compare this dosage regimen with twice-daily administration for optimal treatment outcomes.