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Dermatologic Manifestation of Acro-Ischemia Associated With COVID-19
Robert Gumbita1, Jason Z Liu1, Rohan Madhu Prasad1
1Department of Internal Medicine, Michigan State University, Sparrow Hospital, Lansing, MI.
Insights
A COVID-19 patient developed painful skin lesions on his toes. Guideline-based treatment with anticoagulants resolved these acro-ischemia symptoms, highlighting a treatable dermatologic manifestation of coronavirus disease 2019.
Area of Science:
- Dermatology
- Infectious Diseases
- Vascular Medicine
Background:
- Coronavirus disease 2019 (COVID-19) presents with diverse dermatologic manifestations.
- Acro-ischemia, a rare skin complication, is not well-documented in COVID-19 patients.
- Understanding COVID-19's impact on skin is crucial for comprehensive patient care.
Observation:
- A 73-year-old male with COVID-19 developed acute hypoxic respiratory failure.
- The patient presented with painful, violaceous purpura on his lower extremity digits.
- This indicated a severe manifestation of acro-ischemia.
Findings:
- The patient received therapeutic enoxaparin and nitroglycerin ointment.
- Upon discharge, apixaban was prescribed for continued treatment.
- The acro-ischemic lesions showed resolution with this medical management.
Implications:
- Dermatologic manifestations are part of COVID-19's multiorgan impact.
- Acro-ischemia in COVID-19 can be effectively treated with standard anticoagulation therapy.
- This case underscores the importance of recognizing and managing skin symptoms in COVID-19.
Abstract:
Background: The common dermatologic manifestations seen in patients with coronavirus disease 2019 (COVID-19) include morbilliform, pernio-like, urticarial, macular erythematous, vesicular, and papulosquamous disorders, as well as retiform purpura. Although cases of acro-ischemia have been demonstrated, they are not well studied or reported. Case Report: A 73-year-old male was admitted for acute hypoxic respiratory failure secondary to COVID-19 infection. During the patient's hospital course, his oxygen requirement progressively increased, and he developed painful, violaceous purpura on his right lower extremity digits. The patient was treated with therapeutic doses of enoxaparin and nitroglycerin ointment in the hospital and apixaban on discharge. The patient was lost to follow-up. Conclusion: The multiorgan dysfunction associated with COVID-19 includes dermatologic manifestations. This case illustrates that acro-ischemia can resolve with guideline-based medical treatment.
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