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The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian
Yu Yang1, Yang Xiaohui1, Sui Miao1
1Endocrinology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Background:
In this study, we performed a bidirectional mendelian randomization analysis on circulating cytokines and critically ill COVID-19.
Methods:
Both the exposure and outcome data were obtained from public genome wide association study (GWAS) database. We extracted independent instrumental variables from exposure at genome level significance (P < 5 × 10-8). Wald ratio or inverse variance weighted (IVW) method were used for estimating the causal relationships between circulating cytokines and critically ill COVID-19.
Results:
Only IL5 (cytokines to critically ill COVID-19 direction) and bNGF, IL8 (critically ill COVID-19 to cytokines direction) showed suggestive causal relations. However, these associations lost significance after FDR correction. Another validation data set of critically ill COVID-19 did not confirm these associations, either.
Conclusions:
Our Mendelian randomization did not find causal relationships between analyzable circulating cytokines and critically ill COVID-19.
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