Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.3K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.3K
Whole Body Regeneration01:33

Whole Body Regeneration

3.5K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.5K
Morphogenesis02:19

Morphogenesis

28.9K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.9K
Meristems and Plant Growth02:36

Meristems and Plant Growth

47.2K
Plants grow throughout their lives; this is called indeterminate growth, and it distinguishes plants from most animals. Although certain parts of plants stop growing (e.g., leaves and flowers), others grow continuously—like roots and stems.
47.2K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

58.3K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
58.3K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Dynamic Models for AML Disease Progression from Longitudinal Multi-Modal Clinical Data Using Explainable Machine Learning.

medRxiv : the preprint server for health sciences·2025
Same author

Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth.

bioRxiv : the preprint server for biology·2025
Same author

Mechanistic regulation of planarian shape during growth and degrowth.

Development (Cambridge, England)·2024
Same author

Automatic design of gene regulatory mechanisms for spatial pattern formation.

NPJ systems biology and applications·2024
Same author

<i>mergem</i>: merging, comparing, and translating genome-scale metabolic models using universal identifiers.

NAR genomics and bioinformatics·2024
Same author

Kinetic modeling of microbial growth, enzyme activity, and gene deletions: An integrated model of β-glucosidase function in Cellvibrio japonicus.

Biotechnology and bioengineering·2020

Related Experiment Video

Updated: Sep 28, 2025

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

8.7K

Formalizing Phenotypes of Regeneration.

Daniel Lobo1

  • 1Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA. lobo@umbc.edu.

Methods in Molecular Biology (Clifton, N.J.)
|April 1, 2022
PubMed
Summary

This study introduces standardized protocols for formalizing regeneration phenotypes using mathematical descriptions and gene expression patterns. This approach facilitates the extraction of mechanistic knowledge and the development of systems-level models for regeneration research.

Keywords:
FormalizationInferenceModelingRegeneration

More Related Videos

Methods for the Study of Regeneration in Stentor
08:48

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

11.9K
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

9.0K

Related Experiment Videos

Last Updated: Sep 28, 2025

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

8.7K
Methods for the Study of Regeneration in Stentor
08:48

Methods for the Study of Regeneration in Stentor

Published on: June 13, 2018

11.9K
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
09:17

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

Published on: July 12, 2019

9.0K

Area of Science:

  • Developmental Biology
  • Systems Biology
  • Bioinformatics

Background:

  • Regeneration experiments yield complex phenotypes (morphological, gene expression) vital for understanding regeneration mechanisms.
  • Extracting mechanistic knowledge is challenging due to data complexity, individual variability, and scattered literature.

Purpose of the Study:

  • To present protocols for unambiguously formalizing regeneration phenotypes and experimental procedures.
  • To enable the extraction of mechanistic knowledge from regeneration data.
  • To facilitate the development of comprehensive systems-level models of regeneration.

Main Methods:

  • Formalizing phenotypes using precise mathematical morphological descriptions.
  • Standardizing gene expression patterns.
  • Illustrating protocols with step-by-step examples for planaria and limb regeneration.

Main Results:

  • Developed a methodology to formalize regeneration phenotypes and experimental procedures.
  • Created curated datasets based on the formalized methods.
  • Demonstrated applicability to planaria and limb regeneration.

Conclusions:

  • The formalized datasets serve as a key resource for human scientists and computational methodologies.
  • This approach supports automatic extraction of mechanistic knowledge through reverse engineering.
  • Paves the way for discovering comprehensive systems-level models of regeneration.