Bone Density and Structure in Overweight Men With and Without Diabetes.
Jakob Starup-Linde1,2,3, Marie Juul Ornstrup1, Thomas Nordstrøm Kjær1
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Frontiers in Endocrinology
|April 1, 2022
Summary
Overweight men with type 2 diabetes (T2D) showed lower bone turnover than those with metabolic syndrome (MetS), indicating T2D itself, not obesity, impacts bone health. Bone density and structure differences were not clinically significant across groups.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Bone Biology
Background:
- Metabolic syndrome (MetS), type 1 diabetes (T1D), and type 2 diabetes (T2D) are linked to increased fracture risk.
- The specific influence of obesity on bone deficits in diabetic individuals remains unclear.
Purpose of the Study:
- To compare bone structure, density, and turnover markers in non-diabetic overweight men with MetS versus overweight men with T1D or T2D.
Main Methods:
- Cross-sectional study including participants with diabetes (T1D, T2D) and MetS.
- Dual-energy X-ray absorptiometry (aBMD) and High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) were used.
- Circulating bone turnover markers were measured and analyzed with statistical adjustments.
Main Results:
- Bone turnover markers were comparable between T1D and MetS groups.
- Individuals with T2D had lower bone turnover markers (P1NP, Osteocalcin) than MetS, despite similar areal bone mineral density (aBMD) after adjustments.
- No significant differences in volumetric bone mineral density (vBMD) were found between MetS and T1D/T2D groups at the tibia or radius.
Conclusions:
- No clinically significant differences in bone density or structure were observed between men with T2D, T1D, or MetS.
- Type 2 diabetes, independent of obesity, is associated with reduced bone turnover compared to metabolic syndrome.
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