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Natural Approach in Osteoarthritis Therapy
Alice Grigore1, Virginia Vulturescu2
1National Institute for Chemical-Pharmaceutical Research and Development-ICCF Bucharest, Pharmaceutical Biotechnologies Department, Calea Vitan, No. 112, 3rd District, 031299 Bucharest, Romania.
Recent Advances in Inflammation & Allergy Drug Discovery
|April 1, 2022
Summary
Osteoarthritis (OA), a common inflammatory joint disease, lacks effective cures. This review explores herbal medicines, particularly their anti-inflammatory and antioxidant properties, for potential OA therapy, especially via intra-articular injection.
Area of Science:
- Rheumatology
- Pharmacology
- Natural Products
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage destruction and inflammation.
- Current OA treatments primarily manage symptoms or slow progression, with no definitive cure available.
- Intra-articular (IA) therapy offers advantages over oral administration for OA treatment due to improved bioavailability and reduced systemic toxicity.
Approach:
- This review examines the therapeutic potential of herbal medicines for osteoarthritis.
- It focuses on the anti-inflammatory and antioxidant properties of plant-derived compounds relevant to OA.
- The review also explores the limited research on intra-articular injections of herbal extracts and their potential combination therapies.
Key Points:
- Herbal medicines possess anti-inflammatory and antioxidant properties beneficial for managing OA.
- Intra-articular administration of herbal therapies presents a promising route for enhanced efficacy and safety.
- Further research is needed to develop and clinically test novel natural pharmaceutical formulations for OA.
Conclusions:
- Herbal medicine offers a promising avenue for novel osteoarthritis therapies, particularly through intra-articular administration.
- Developing safe, bioavailable, and targeted natural formulations could significantly advance OA treatment.
- This review highlights the need for further investigation into plant-based compounds for effective OA management.
