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Related Concept Videos

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
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The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Theranostic Trigger-Responsive Carbon Monoxide-Generating Microbubbles.

Vertika Pathak1, Karolin Roemhild1,2, Sandra Schipper1,3

  • 1Institute for Experimental Molecular Imaging, Medical Faculty, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University Clinic, 52074, Aachen, Germany.

Small (Weinheim an Der Bergstrasse, Germany)
|April 1, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed novel light-triggerable polymeric microbubbles loaded with a carbon monoxide (CO)-releasing molecule. This platform enables targeted CO delivery and monitoring for treating cardiovascular disease and reducing cell damage.

Keywords:
carbon monoxide therapycardiovascular diseasemicrobubblespoly-n-butyl-cyanoacrylate (PBCA)ultrasound

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Carbon monoxide (CO) is a crucial signaling molecule for cardiovascular health, but its therapeutic use is limited by handling difficulties.
  • Existing CO delivery methods lack targeted control and real-time monitoring capabilities.

Purpose of the Study:

  • To develop a novel drug delivery platform for targeted and image-guided carbon monoxide (CO) therapy.
  • To create light-triggerable, MRI- and ultrasound-imageable CO-releasing polymeric microbubbles (COMB).

Main Methods:

  • Synthesis of CORM-1-loaded polymeric microbubbles (COMB) via a one-step protocol.
  • Characterization of COMB size, CO release kinetics, and imaging properties (MRI and US).
  • In vitro evaluation of COMB-mediated CO release effects on hemoglobin saturation, macrophage differentiation, ROS production, and apoptosis.

Main Results:

  • COMB demonstrated efficient CORM-1 loading, a narrow size distribution (peak at 2 µm), and dual-mode imaging (MRI/US) capabilities.
  • Light irradiation triggered localized CO release from COMB, confirmed by MRI monitoring of relaxation rates.
  • COMB-mediated CO release showed therapeutic potential by saturating hemoglobin, inducing anti-inflammatory macrophage responses, reducing ROS, and inhibiting apoptosis in cardiovascular cells.

Conclusions:

  • COMB represent a promising theranostic platform for image-guided, light-triggered CO delivery.
  • This technology offers a potential strategy to mitigate hypoxia-associated and ROS-mediated damage in cardiovascular diseases.
  • COMB facilitate targeted CO therapy with enhanced monitoring, addressing limitations of traditional CO gas administration.