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Cefsulodin.

D B Wright

    Drug Intelligence & Clinical Pharmacy
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cefsulodin is a narrow-spectrum cephalosporin effective against Pseudomonas aeruginosa. While generally well-tolerated, its use is limited to specific P. aeruginosa infections where other treatments fail or aminoglycosides are contraindicated.

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    Area of Science:

    • Pharmacology
    • Microbiology
    • Clinical Medicine

    Background:

    • Cefsulodin is a third-generation cephalosporin antibiotic.
    • Its antimicrobial spectrum is primarily limited to Pseudomonas aeruginosa.
    • Comparison with ceftazidime and cefoperazone is relevant for clinical application.

    Purpose of the Study:

    • To review the chemistry, microbiology, pharmacokinetics, adverse reactions, and clinical indications of cefsulodin.
    • To compare cefsulodin with ceftazidime and cefoperazone.
    • To evaluate the potential role of cefsulodin in specific clinical scenarios.

    Main Methods:

    • Literature review of cefsulodin, ceftazidime, and cefoperazone.
    • Analysis of pharmacokinetic and pharmacodynamic properties.

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  • Assessment of clinical efficacy and safety data.

    • Main Results:

    • Cefsulodin exhibits narrow-spectrum activity, mainly against Pseudomonas aeruginosa.
    • Renal elimination and serum half-life are comparable to ceftazidime and cefoperazone.
    • Adverse effects are minimal, with nausea and vomiting linked to infusion rate.

    Conclusions:

    • Cefsulodin may be useful for infections caused by susceptible P. aeruginosa strains resistant to other antipseudomonal cephalosporins.
    • It offers an alternative when aminoglycoside avoidance is necessary.
    • Empiric use of cefsulodin is not recommended due to its narrow spectrum.