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Related Experiment Video

Updated: Sep 28, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Published on: February 7, 2021

Patient-derived explants as tumor models.

Christopher G Hubert¹, Jeremy N Rich²

¹Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

|April 1, 2022

Summary

This summary is machine-generated.

Patient-derived explants accurately model tumor ecosystems, including diverse cancer cells and stromal elements. This research highlights their value for predictive modeling in cancer research.

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Last Updated: Sep 28, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Published on: February 7, 2021

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Published on: November 29, 2018

Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research

Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research

Published on: May 5, 2021

Area of Science:

Oncology
Translational Research
Single-cell Biology

Background:

Tumors are complex ecosystems with diverse neoplastic and stromal cells.
This heterogeneity complicates the development of accurate predictive tumor models ex vivo.

Purpose of the Study:

To evaluate patient-derived explants as models for replicating tumor cell diversity.
To assess the capacity of these models to capture transient stromal cell types.

Main Methods:

Utilized single-cell analysis techniques.
Compared cellular composition of patient-derived explants with patient surgical specimens.

Main Results:

Patient-derived explants successfully replicated the diversity of neoplastic cells found in tumors.
These explants also captured the transient stromal cell types present in patient samples.
Demonstrated a high degree of fidelity in modeling the tumor microenvironment.

Conclusions:

Patient-derived explants serve as valuable and accurate models for studying complex tumor ecosystems.
These models hold significant potential for advancing predictive modeling in cancer research and drug development.