Mesoporous silica size, charge, and hydrophobicity affect the loading and releasing performance of lambda-cyhalothrin

Nanopesticides are attracting increasing attention as a promising technology in agriculture to improve insecticidal efficacy, decrease pesticides uses, and reduce potential environmental impacts. We synthesized mesoporous silica nanoparticles, i.e., Mobil Composition of Matter No.48 (MCM-48), with different sizes (63-130 nm), charges (-22 to 12 mV), and hydrophobicity (water contact angle 29-103°) to assess their loading amount and release of a typical poorly soluble halogenated pyrethroid (i.e., lambda-cyhalothrin particles, LCNS). The smallest MCM-48 displayed relatively higher loading amount of LCNS (~16%) compared to the larger MCM-48 nanoparticles, likely because of its higher pore volume (1.46 cm³ g^-1) and pore size (3.56 nm). LCNS loading amount was further improved to ~26% and ~36% after -NH₂ (positively charged) and -CH₃ (hydrophobic) functionalization, respectively, probably due to hydrogen bonding, electrostatic, and hydrophobic interactions with LCNS. Loading LCNS in MCM-48 nanoparticles also significantly improved its dispersion in water and ultraviolet (UV) light stability, with a 3-7 times longer half-life than that of free LCNS. Although the -NH₂ and -CH₃ modifications of MCM-48 slightly decreased the UV stability of LCNS, they significantly decreased the release efficiency of LCNS, possibly because of their stronger interactions with LCNS. In addition, the insecticidal effects of LCNS-loaded MCM-48 were more efficient and longer than those of free LCNS. The findings clarify the relationships between physicochemical properties and performance of mesoporous silica nanoparticles, and will inform the rational design of materials for controlled release of pesticides and sustainable control of pests.