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Small Fiber Neuropathy in Sarcoidosis.

Natalia Gavrilova^1,2, Anna Starshinova², Yulia Zinchenko^1,2

¹St. Petersburg Scientific Research Institute of Phthisiopulmonology, 191036 Saint-Petersburg, Russia.

Pathophysiology : the Official Journal of the International Society for Pathophysiology

|April 2, 2022

Summary

This summary is machine-generated.

Small fiber neuropathy (SFN) affects up to 60% of sarcoidosis patients, often linked to systemic inflammation. This study identified clinical and histological markers, revealing dysautonomia and sensory dysfunction as common symptoms.

Keywords:

autoimmune inflammation autoimmunity polyneuropathy sarcoidosis small fiber neuropathy

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Published on: January 3, 2011

Area of Science:

Neurology
Immunology
Dermatology

Background:

Sarcoidosis (SC) is an idiopathic granulomatous disease.
Small fiber neuropathy (SFN) is a common neurological complication of SC, often linked to chronic inflammation.
SFN in sarcoidosis remains understudied, necessitating research into its clinical and histological correlates.

Purpose of the Study:

To identify clinical and histological correlates of small fiber neuropathy (SFN) in patients with sarcoidosis.
To investigate the association between SFN symptoms and objective measures in sarcoidosis patients.

Main Methods:

A study involving 50 participants (25 with pulmonary sarcoidosis, 25 healthy controls) conducted in 2018-2019.
Clinical assessment using the "Small Fiber Neuropathy Screening List" (SFN-SL).
Histological analysis via skin punch biopsy and enzyme immunoassay with PGP 9.5 antibodies to determine intraepidermal nerve fiber density (IEND).

Main Results:

Up to 60% of sarcoidosis patients reported symptoms potentially related to SFN, including cardiovascular, musculoskeletal, and gastrointestinal complaints.
A significant negative correlation was found between IEND and SFN-SL scores.
Common symptoms observed were dysautonomia and mild sensory dysfunction.

Conclusions:

Small fiber neuropathy may develop in sarcoidosis patients due to systemic immune-mediated inflammation.
Clinical screening tools and histological analysis are crucial for identifying SFN in sarcoidosis.
Further research is warranted to understand the pathogenesis and management of SFN in sarcoidosis.