Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Casein-Lecithin Nanoemulsions Co-Encapsulating Vitamin E and Carvacrol as Multifunctional Edible Coatings for Meat Preservation.

Gels (Basel, Switzerland)·2026
Same author

n-Type Polymer Radio Frequency Rectifiers Operating at 18.5 GHz.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Architecture Effect on Network Phase Formation from Controlled Self-Assembly of High‑χ Block Copolymers.

Macromolecules·2026
Same author

Rational Design of New Biocompatible Near-Infrared Conjugated Polymer Nanoparticles for Biomedical Applications.

Macromolecules·2026
Same author

Advances and Applications of Block Copolymers II.

Polymers·2026
Same author

160 GHz Schottky Diodes from Solution-Processed IGZO.

Small (Weinheim an der Bergstrasse, Germany)·2025

Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K

Smartphone paired SIM card-type integrated creatinine biosensor.

Εleni I Tzianni1, Ioannis Moutsios2, Dimitrios Moschovas2

  • 1Laboratory of Analytical Chemistry, University of Ioannina (UoI), 45 110, Ioannina, Greece.

Biosensors & Bioelectronics
|April 2, 2022
PubMed
Summary
This summary is machine-generated.

A novel smartphone-integrated paper-based biosensor uses a pH-responsive polymer and creatinine deiminase (CD) to detect urinary creatinine levels. This affordable device offers selective and automated analysis for medical diagnostics.

Keywords:
Bluetooth wireless connected biosensorsCreatininePaper-based biosensorsPoint-of-careUrinary analysispH responsive polymer membranes

More Related Videos

Low-Cost, Volume-Controlled Dipstick Urinalysis for Home-Testing
06:55

Low-Cost, Volume-Controlled Dipstick Urinalysis for Home-Testing

Published on: May 8, 2021

5.7K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

1.0K

Related Experiment Videos

Last Updated: Sep 28, 2025

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K
Low-Cost, Volume-Controlled Dipstick Urinalysis for Home-Testing
06:55

Low-Cost, Volume-Controlled Dipstick Urinalysis for Home-Testing

Published on: May 8, 2021

5.7K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

1.0K

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • The medical diagnostic sector requires affordable, handheld devices for efficient clinical analysis.
  • Smart biosensing and transducing interfaces are crucial for minimal end-user intervention and resource requirements.

Purpose of the Study:

  • To propose a SIM card-type, pH-responsive polymer-modified paper-based biosensing device for smartphone-coupled urinary creatinine determination.
  • To develop a selective and automated method for measuring creatinine concentrations.

Main Methods:

  • Fabrication of a vertical microfluidic channel on a paper strip using wax printing.
  • Coating the hydrophilic area with a poly(methylmethacrylate)/poly(methacrylic acid) random copolymer (PMMA-co-PMAA) and immobilizing creatinine deiminase (CD).
  • Utilizing electric resistance measurements via conductive strips for automatic measurement of copolymer degradation time.

Main Results:

  • Demonstrated zero vertical flow in enzyme-free modified strips, indicating high matrix selectivity.
  • Observed creatinine-concentration-dependent downward flow due to CD-triggered copolymer degradation by ammonia.
  • Successfully adjusted the detection range (3-30 mM creatinine) by synthesizing PMMA-co-PMAA with tunable dissolution properties.

Conclusions:

  • The developed CD/PMMA-co-PMAA paper-based biosensing device coupled with a smartphone enables accurate urinary creatinine determination.
  • The device offers an affordable, selective, and automated solution for point-of-care diagnostics.
  • Tunable polymer properties allow for adaptation to different physiological ranges of urinary creatinine.