Risk factors of the post-reperfusion syndrome during orthotopic liver transplantation: a clinical observational study
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Updated: Jul 12, 2026
Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
Mohammad Ali Sahmeddini1, Samaneh Ghazanfar Tehran2,3, Mohammad Bagher Khosravi1
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Post reperfusion syndrome (PRS) is a relatively common and life-threatening complication during orthotopic liver transplantation (OLT). It is associated with poor patient and transplanted liver outcomes.
Objective:
This study aimed to compare the risk factors of PRS during OLT.
Design:
Clinical-epidemiological observational retrospective study.
Setting:
We gathered the records of patients who underwent OLT in 3 years, from May 22, 2016, to May 22, 2019, in Namazi and Bu-Ali Sina organ transplantation hospitals.
Patients:
In this study, we assessed 1182 patients who underwent OLT. Patients were divided into two groups based on the presence or absence of PRS.
Main Outcome Measures:
Diagnosing the predictors of PRS was the primary outcome of this study.
Results:
Results showed that age > 60 years, Child-Pugh scores C, higher Model End Stage liver disease score, and preoperative sodium < 130 mmol/l (parameters of the liver recipient), increase in cold ischemic time (the donors' parameters), and the classical technique (the surgical parameters) were the strong predictors of PRS.
Conclusions:
The results indicated that underlying liver disease was not the predictor of PRS in the presence of other risk factors; therefore, clinicians have to consider these risk factors in patients undergoing OLT.
